A convenient method for 14C-labeling of N-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as CCK-A antagonist

نویسندگان

  • Gholamhossein Shirvani Nuclear science Research School, Nuclear Science & Technology Research Institute
  • Mohsen Javaheri Nuclear science Research School, Nuclear Science & Technology Research Institute
  • Nader Saemian Nuclear science Research School, Nuclear Science & Technology Research Institute
چکیده مقاله:

N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.

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a convenient method for 14c-labeling of n-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as cck-a antagonist

n-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14c-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14c] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14c]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.

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عنوان ژورنال

دوره 5  شماره 2

صفحات  103- 107

تاریخ انتشار 2012-06-20

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